Katchoo and Francine, two young women who have been friends since school-time, share a house. Katchoo is an aspiring artist. Francine is in a rather stressful relationship with Freddie Femurs. The stress arises from the fact that Francine, emotionally damaged from too many "friendships" gone sour, wants to wait with sex until she can be sure that Freddie will not leave her afterwards.