The title refers to an actual group of 19th-century Bostonians who gathered to translate Dante's Inferno for an American audience. Among the members of this exclusive "club" were poet Henry Wadsworth Longfellow, physician Oliver Wendell Holmes, and poet James Russell Lowell. While poring over the poem, the men find themselves on the trail of a serial killer who tortures his victims in ways that seem to be taken straight out of the pages of Inferno. The police are at a loss and must rely on the club members' unique knowledge of Dante's work to help catch the killer.