Alec Holland rises from death into a mass of vegetation called the Swamp Thing to wreck havoc upon nature at the cost of billions of lives, and the only one who has the power to stop him is his daughter, Tefe.
Swamp Thing follows his girlfriend Abby to Gotham City after Abby is prosecuted for her relationship with him, where he clashes with Batman, Lex Luthor, and the Gotham City Police Department.
Caught in an explosion in his laboratory where he was working on a top-secret research project, scientist Alex Holland falls burning into the Louisiana swamp and is transformed into the Swamp Thing, and then sets out to find those responsible for destroying his life.