When a little rat named Remy tries to become a chef in a famous French restaurant, his passion for cooking soon turns the culinary world of Paris upside down.
With nowhere else to turn, a field mouse asks the clever escaped lab rats living under the rosebush to help save her son, who lies in the path of the farmer's tractor, too ill to be moved.
Rat brothers Louie and Ralphie Ratso try to prove they can be as rough and tough as their father in the Big City, but every time they try to show how tough they are, they end up accidentally doing good deeds instead.
Twelve-year-old Rudi stumbles upon a witch's lair while out hunting, takes a gold coin he finds there but loses it again, then must deal with the witch's servant who promises to end the town's rat infestation only if he receives that gold coin, in a story reminiscent of The Pied Piper of Hamelin.
A rat named Remy dreams of becoming a gourmet chef but his father has other plans for him. Then Remy befriends a kitchen hand who lets him cook meals in a fancy Parisian restaurant which leads to the creation of a special dish called ratatouille.
During a London vacation, Oz Levinson must deal with the bullying Priscilla Winterbottom, while mouse spy Glory Goldenleaf tracks the whereabouts of a valuable jewel, missing orphaned mouselings, and two evil ministers of rats.
When the infamous and formerly illiterate rat leader Roquefort Dupont is found reading a book at the Library of Congress, the mice fear that their future is bleak.