After seeking to live a normal life, Logan sets out to avenge the death of his girlfriend by undergoing the mutant Weapon X program and becoming Wolverine.
When a cure is found to treat mutations, lines are drawn amongst the X-Men, led by Professor Charles Xavier, and the Brotherhood, a band of powerful mutants organized under Xavier's former ally, Magneto.
The X-Men band together to find a mutant assassin who has made an attempt on the President's life, while the Mutant Academy is attacked by military forces.