After Buster defeats the Brain in a math contest, the Brain declares Buster the new brain and decides to become a comedian, until his friends convince him that he is still as smart as ever.
Alfred the aardvark lives with his mother on the "A" page of the dictionary, and when his pet ant, Itty Bitty, slips out of the ant farm to visit the zoo, Alfred goes after him, digging all the way down to "Z.".
Unhappy about how much homework they have to do, Arthur and his friends dare each other to skip school, but their plans go wrong, leaving Francine to suffer the consequences.