After her brother Jared dies, ten-year-old Annie worries about the hidden dangers of everything, from bug bites to bicycle riding, until she is befriended by a new neighbor who is grieving her own loss.
Eleven-year-old Adam, a boy whose freckles can see and talk, tries to get them to help him watch for sharks during his family's Cape May vacation. But the freckles are in the middle of a revolution, leaving Adam to sort out his problems with the help of a new friend, a blind boy named Seth.
First-grader Jessica, a big worrier, is especially afraid that she will make a mistake when she is reading in front of her class and parents on Reading Theater Day, but after lots of practice reading to her dog Wiggles, she performs perfectly.
A mouse named Wemberly, who worries about everything, finds that she has a whole list of things to worry about when she faces the first day of nursery school.
When the teacher tells her class that they can think of almost everything as a math problem, one student acquires a math anxiety which becomes a real curse.
Clarice Bean tries to glean useful advice from the "Ruby Redfort Survival Handbook" as she deals with several worries, including "largish" spiders, Robert the pest, and, most of all, sudden change.